![]() The NONMEM Ò implementation of the MAv using the abbreviated FOR-TRAN function FUNCA is described and explained. This paper explains the basis of the MAv by means of a simple mathematical derivation. repeats its values in regular intervals) and the rate of change of the PD response is such that it is approximately constant over a single period of the PK profile. The MAv gives an approximate solution, which is expected to be a good approximation when the PK profile is periodic (i.e. This burden can be greatly reduced by applying the method of averaging (MAv) in the appropriate circumstances. ![]() The computational effort required to fit the pharmacodynamic (PD) part of a pharmacokinetic/phar-macodynamic (PK/PD) model can be considerable if the differential equations describing the model are solved numerically. ![]()
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